CYP3A4 is one of the busiest drug-metabolizing enzymes in the liver. Strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, clarithromycin, or ritonavir) can slow trazodone's breakdown and raise blood levels, increasing side-effect risk. Strong inducers (such as carbamazepine, phenytoin, or rifampin) can speed up its breakdown and reduce effectiveness. See our Interaction Library for specific combinations.
CYP3A4
Also called: Cytochrome P450 3A4
A liver enzyme responsible for metabolizing many medications, including trazodone. Drugs that strongly inhibit or induce CYP3A4 can significantly raise or lower trazodone levels in the blood.