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Trazodone for Anxiety

How trazodone is sometimes used off-label for anxiety symptoms, and how it differs from medications specifically approved for anxiety.

Editorially reviewed
Key points
  • Not FDA-approved for any anxiety disorder
  • Sometimes used off-label, especially for anxiety-related sleep trouble
  • Usually not a first-line anxiety treatment on its own

Trazodone is not FDA-approved for any anxiety disorder, but it is sometimes prescribed off-label, particularly when anxiety and sleep disruption or depression coexist. Its sedating and serotonergic properties may help with some anxiety symptoms, though it is not typically a first-line anxiety treatment the way SSRIs, SNRIs, or buspirone often are.

Some prescribers use low-dose trazodone specifically at night for anxiety-related insomnia, while managing daytime anxiety symptoms with a different, more anxiety-specific medication. This is an individualized decision that depends on your full symptom picture.

References

  1. Trazodone: MedlinePlus Drug Information. U.S. National Library of Medicine (MedlinePlus). View source (opens in a new tab) Accessed August 8, 2026
  2. Trazodone Hydrochloride Tablets — FDA Prescribing Information. DailyMed / U.S. Food & Drug Administration. View source (opens in a new tab) Accessed August 8, 2026
Not medical advice. This article is educational and does not replace guidance from your prescriber or pharmacist. If you think you're having a serious reaction, see our emergency resources page.

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