Carbamazepine, used for seizures and certain mood disorders, is a strong inducer of CYP3A4 — the liver enzyme mainly responsible for metabolizing trazodone. Combined use can substantially lower trazodone blood levels, potentially making a normal dose less effective. Prescribers may need to increase the trazodone dose or monitor response more closely.
Trazodone and carbamazepine
Carbamazepine strongly induces the CYP3A4 enzyme that breaks down trazodone, which can significantly lower trazodone blood levels and reduce its effectiveness.
Editorially reviewed
Key points
- A strong CYP3A4 inducer
- Can significantly reduce trazodone's effectiveness at a normal dose
- May require trazodone dose adjustment
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.