Dextromethorphan is in many combination cough and cold products (often labeled "DM"). It has mild serotonergic activity, and case reports describe serotonin syndrome when combined with serotonergic antidepressants at higher doses. Check the label of any cough/cold product before use, or ask a pharmacist.
Trazodone and dextromethorphan (DXM)
Dextromethorphan, found in many over-the-counter cough and cold products, has serotonergic activity that can add to trazodone's effects.
Editorially reviewed
Key points
- Found in many combination cough/cold products
- Check labels for "DM" or dextromethorphan before use
- Ask a pharmacist if unsure about a specific product
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.