Digoxin, used for certain heart conditions, has a notably narrow therapeutic range — the difference between an effective dose and a toxic one is small. Documented case reports describe trazodone increasing digoxin blood levels. Anyone on digoxin who starts trazodone should have digoxin levels monitored more closely, especially early in treatment.
Trazodone and digoxin
Case reports and pharmacology literature describe trazodone increasing digoxin blood levels, which matters because digoxin has a narrow safety margin.
Editorially reviewed
Key points
- Digoxin has a narrow safety margin by nature
- Case reports describe increased digoxin levels with trazodone
- Closer monitoring is reasonable when starting this combination
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.