Grapefruit and grapefruit juice inhibit intestinal CYP3A4, a mechanism well documented for many other medications (like some statins and calcium channel blockers). Because trazodone is metabolized via this pathway, regularly consuming grapefruit products alongside trazodone may raise blood levels somewhat. If you eat or drink grapefruit regularly, mention it to your prescriber.
Trazodone and grapefruit juice
Grapefruit is a well-known CYP3A4 inhibitor for many medications, and some data suggests it can raise trazodone levels similarly to prescription CYP3A4 inhibitors.
Editorially reviewed
Key points
- Grapefruit is a well-known CYP3A4 inhibitor generally
- May modestly raise trazodone levels with regular consumption
- Mention regular grapefruit intake to your prescriber
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.