Methylene blue is used in specific clinical situations, including as a diagnostic dye and to treat methemoglobinemia. Like linezolid, it inhibits monoamine oxidase, creating a serotonin syndrome risk when combined with trazodone or other serotonergic antidepressants. Hospital staff should always be told about current antidepressant use before this drug is administered.
Trazodone and methylene blue
Methylene blue, used in certain medical procedures and to treat methemoglobinemia, also has MAOI-like activity and carries the same serotonin syndrome caution as linezolid.
Editorially reviewed
Key points
- Has MAOI-like activity similar to linezolid
- Relevant mainly in hospital/procedural settings
- Always disclose current antidepressants before this drug is given
Seek urgent care if you notice:
- Fever, agitation, or rigidity after administration
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.