NSAIDs like ibuprofen and naproxen already carry some GI bleeding risk on their own by affecting the stomach lining and platelet function. Serotonergic antidepressants, including trazodone, can add a modest additional bleeding-risk effect through platelet activity. Occasional use is generally not a major concern for most people, but regular NSAID use alongside trazodone is worth mentioning to a prescriber, especially for anyone with other bleeding risk factors.
Trazodone and NSAIDs
Combining a serotonergic medication with NSAIDs may modestly increase bleeding risk, particularly gastrointestinal bleeding, compared with either alone.
Editorially reviewed
Key points
- Both can independently affect bleeding risk
- Occasional use is generally lower concern than regular use
- Mention regular NSAID use to your prescriber
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.