Azithromycin, moxifloxacin, and some related antibiotics carry their own QT-prolongation warnings. Combined with trazodone during a short antibiotic course, this raises cardiac rhythm risk somewhat, particularly for people with other heart rhythm risk factors. Mentioning current trazodone use whenever a new antibiotic is prescribed helps the prescriber choose an alternative if needed.
Trazodone and QT-prolonging antibiotics
Certain antibiotics, including some macrolides and fluoroquinolones, also affect the QT interval, adding to trazodone's own documented cardiac rhythm effect.
Editorially reviewed
Key points
- Several common antibiotics carry independent QT warnings
- Relevant mainly for the duration of a short antibiotic course
- Always mention current medications when prescribed a new antibiotic
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.