Rifampin is one of the strongest known inducers of CYP3A4. In someone taking trazodone, starting rifampin can lower trazodone blood levels enough to reduce its effect on mood or sleep. This is particularly relevant for tuberculosis treatment courses, which often last months.
Trazodone and rifampin
Rifampin, used to treat tuberculosis and some other infections, is a strong CYP3A4 inducer that can meaningfully reduce trazodone's effectiveness.
Editorially reviewed
Key points
- A strong, well-documented CYP3A4 inducer
- Effect can last through a multi-month TB treatment course
- May require increased monitoring or a dose adjustment
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.