Ritonavir, used in HIV treatment (often as a "booster" for other antiretrovirals), is a particularly potent CYP3A4 inhibitor. Combined with trazodone, it can significantly raise trazodone blood levels and side-effect risk. People on ritonavir-containing regimens who are prescribed trazodone should have this combination specifically reviewed by their care team, likely with a lower starting trazodone dose.
Trazodone and ritonavir (HIV protease inhibitors)
Ritonavir is one of the strongest known CYP3A4 inhibitors and is specifically discussed in trazodone's pharmacokinetic literature for this reason.
Editorially reviewed
Key points
- One of the most potent known CYP3A4 inhibitors
- Significant trazodone level increase is possible
- A lower trazodone starting dose is often appropriate
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.