Tramadol is an opioid pain reliever that also has meaningful serotonergic activity, which is why it appears on serotonin syndrome interaction lists more often than most other opioids. It can also lower the seizure threshold — a concern trazodone shares to a lesser degree. This combination should be managed carefully by a prescriber aware of both risks.
Trazodone and tramadol
Tramadol has serotonergic activity in addition to its opioid effects, adding both serotonin syndrome and seizure-threshold concerns when combined with trazodone.
Editorially reviewed
Key points
- Tramadol is serotonergic in addition to being an opioid
- Both drugs can affect seizure threshold
- Manage this combination under close prescriber supervision
Seek urgent care if you notice:
- Any seizure activity
- Agitation, tremor, or high fever
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.