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Questions to Ask Before Starting Trazodone

A printable checklist of questions to bring to your appointment before starting trazodone, covering dosing, interactions, and what to expect.

Version dated August 8, 2026

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  • What is this being prescribed for — depression, sleep, or something else?
  • What dose am I starting at, and how might it change over time?
  • When during the day should I take it, and with or without food?
  • How long until I should expect to notice an effect?
  • What side effects are most likely, and which ones need immediate medical attention?
  • Do any of my current medications or supplements interact with trazodone?
  • Is it safe to drive after taking it, especially in the first few days?
  • What should I do if I miss a dose?
  • How and when would we plan to stop it, if needed?
  • What symptoms should prompt me to call you versus go to the ER?