Trazodone's official dosing for depression is described in divided doses throughout the day, but because drowsiness is so common, many prescribers direct patients to take the larger portion — or all of it — at bedtime instead. This is a case where your prescriber's specific instructions should guide you, since practice varies by individual response.
Can trazodone be taken once daily instead of multiple times a day?
Short answer: For depression, the label describes divided daily doses, though many prescribers shift most of the dose to bedtime to reduce daytime drowsiness. For off-label sleep use, it is usually taken once, at bedtime.
Editorially reviewed
Not medical advice. This answer is general and educational. Your prescriber knows your full history and can give guidance specific to you.