Like many medications, trazodone's side-effect profile is often most noticeable when starting treatment or after a dose increase, and tends to ease as the body adjusts over the following one to two weeks. Side effects that are severe, worsening, or new after a period of stability deserve a conversation with your prescriber rather than being assumed to be "just adjustment."
How long do trazodone side effects last?
Short answer: Many common side effects — like mild dizziness or dry mouth — improve within the first one to two weeks as the body adjusts. Persistent or worsening effects should be discussed with your prescriber.
Editorially reviewed
Not medical advice. This answer is general and educational. Your prescriber knows your full history and can give guidance specific to you.