Medical emergency
Low blood sodium (hyponatremia)
A drop in blood sodium levels that can become severe, causing confusion, seizures, or worse if untreated — listed directly in trazodone's FDA Medication Guide.
Editorially reviewed
This can be a medical emergency. If you notice these signs in yourself or someone else, call 911 (US) or go to the nearest emergency room immediately. Do not wait to see if it passes.
Key points
- Higher risk for older adults and people on diuretics
- Symptoms can be mistaken for other, milder side effects
- Get medical help right away if several symptoms appear together
Symptoms of hyponatremia listed in trazodone's Medication Guide include headache, feeling weak, confusion, trouble concentrating, memory problems, and feeling unsteady while walking. Older adults and people taking diuretics are generally at higher risk.
Because these symptoms can be mistaken for other side effects (like fatigue or mild confusion), it is worth telling a healthcare provider about the combination of symptoms rather than any single one in isolation, especially if they appear together and worsen.
Call your prescriber or seek care if you notice:
- Headache with confusion or unsteadiness
- New weakness or trouble concentrating
- Seizures (in severe, untreated cases)
Not medical advice. This page describes general patterns reported for trazodone and does not replace individualized guidance from your prescriber or pharmacist.
