Some trazodone users report general muscle aches or joint discomfort. This is usually mild and not specific to trazodone; however, muscle rigidity combined with fever, rapid heartbeat, or agitation could indicate serotonin syndrome and needs urgent evaluation.
Muscle aches and pains
A less commonly reported musculoskeletal side effect, usually mild.
Editorially reviewed
Key points
- Usually mild on its own
- Muscle rigidity with fever and agitation needs urgent care
Not medical advice. This page describes general patterns reported for trazodone and does not replace individualized guidance from your prescriber or pharmacist.