Reported by a meaningful share of trazodone users, particularly early in treatment, and often reduced by taking the dose with food.
Nausea is a common gastrointestinal side effect across many antidepressants that affect serotonin activity, since serotonin receptors are present throughout the gut. Taking trazodone with food can both reduce nausea and change its absorption profile slightly.
Vomiting is less common than nausea alone but is listed in trazodone's overdose reaction profile as well, so vomiting that is severe, persistent, or accompanied by other symptoms warrants medical attention.
The single most common trazodone side effect, caused by the drug's antihistamine-like activity — and the same property that leads to its off…
Read more →A commonly reported digestive side effect, usually mild and self-limiting.
Read more →A commonly reported visual side effect. Trazodone's label also flags eye pain or redness as signs to seek prompt care for a rarer, more seri…
Read more →A common, usually mild anticholinergic-type effect that can be managed with hydration and sugar-free lozenges.
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